She studied at the Conservatori del Liceu and at the Hochschule für Musik Hanns Eisler in Berlin. In 2018 she won the Mozart Prize of the Accademia Chigiana in Siena and the Francisco Viñas International Competition.
As a member of the Berlin Staatsoper Studio, she has sung roles such as Pamina (The Magic Flute), Frasquita (Carmen), and the Forest Bird (Siegfried), the last two operas conducted by Daniel Barenboim. In Berlin she has sung roles such as Zerbinetta (Ariadne auf Naxos), and next season she is scheduled to sing Zerlina (Don Giovanni) and Nanetta (Falstaff).
In the 2025/26 season, Serena Sáenz makes her staged debut as Konstanze in Mozart’s Die Entführung aus dem Serail at the Vienna State Opera, and with the Bavarian State Opera, she gives her eagerly awaited role debut as Gilda in a new production of Verdi’s Rigoletto.
She also debuts as Aminta in Strauss’s Die schweigsame Frau at the Staatsoper Berlin under Christian Thielemann and as Susanna in Barrie Kosky’s production of Le nozze di Figaro at the Vienna State Opera. She returns to the Staatsoper Berlin as Zerbinetta in Ariadne auf Naxos and to the Gran Teatre del Liceu as Nannetta in Verdi’s Falstaff. On the concert stage, Sáenz is heard as the soprano soloist in Beethoven’s Symphony No. 9 with the Orquesta de la Comunidad de Madrid at the Auditorio Nacional, and performs baroque programs with Vespres d’Arnadí in Valencia and Oviedo.
She made her debut at the Gran Teatre del Liceu in the 2020/21 season with Lucia di Lammermoor, returning with The Queen of Spades and The Magic Flute (2021/22), Don Pasquale (2022/23), Benjamin a Portbou (2024/25), and L'elisir d'amore (2025/26).